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Caleb A. Class

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Caleb A. Class

Assistant Professor - Pharmaceutical Sciences

 https://orcid.org/0000-0003-3130-3613

Personal profile

About

My research involves the development of bioinformatic tools to help pharmacists, health professionals and the public better understand complex genomics data, from data processing and analysis pipelines to dashboards for easy visualization. I am also mining and analyzing large metabolomics databases to better understand drug treatment and response mechanisms.
I am also a frequent collaborator with scientists at Butler University and around the country. My contributions have included the processing, analysis, and visualization of different types of 'omics data. Research projects have included the profiling of 'omics data in leukemia, to understand disease progression and treatment response; analysis of gene splicing and polyadenylation patterns to identify treatment mechanisms in pancreatic cancer; and epidemiological analysis to understand why some breast cancer patients do not receive chemotherapy after it is recommended by their doctor.

Related documents

Education/Academic qualification

Biostatistics, Postdoctoral Fellowship, MD Anderson Cancer Center

… → 2018

Chemical Engineering, Ph.D., Massachusetts Institute of Technology

… → 2015

Chemical Engineering Practice, M.S., Massachusetts Institute of Technology

… → 2011

B.S., Purdue University, West Lafayette

… → 2009

Disciplines

  • Medicine and Health Sciences
  • Pharmacy and Pharmaceutical Sciences

  • Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy

    Ganan-Gomez, I., Yang, H., Ma, F., Montalban-Bravo, G., Thongon, N., Marchica, V., Richard-Carpentier, G., Chien, K., Manyam, G., Wang, F., Alfonso, A., Chen, S., Class, C., Kanagal-Shamanna, R., Ingram, J. P., Ogoti, Y., Rose, A., Loghavi, S., Lockyer, P. & Cambo, B. & 18 others, Muftuoglu, M., Schneider, S., Adema, V., McLellan, M., Garza, J., Marchesini, M., Giuliani, N., Pellegrini, M., Wang, J., Walker, J., Li, Z., Takahashi, K., Leverson, J. D., Bueso-Ramos, C., Andreeff, M., Clise-Dwyer, K., =Garcia-Manero, G. & Colla, S., Mar 3 2022, In: Scholarship and Professional Work – COPHS. 28

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Activation of gene expression by detergent-like protein domains

    Broyles, B. K., Gutierrez, A. T., Maris, T. P., Coil, D. A., Wagner, T. M., Wang, X., Kihara, D., Class, C. & Erkine, A. M., Sep 24 2021, In: Scholarship and Professional Work – COPHS. 24

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Hematopoiesis under telomere attrition at the single-cell resolution

    Thongon, N., Ma, F., Santoni, A., Marchesini, M., Fiorini, E., Rose, A., Adema, V., Ganan-Gomez, I., Groarke, E. M., Gutierrez-Rodrigues, F., Chen, S., Lockyer, P., Schneider, S., Bueso-Ramos, C., Montalban-Bravo, G., Class, C., Soltysiak, K. A., Pellegrini, M., Sahin, E. & Bertuch, A. A. & 5 others, DiNardo, C. D., Garcia-Manero, G., Young, N. S., Dwyer, K. & Colla, S., Nov 25 2021, In: Scholarship and Professional Work – COPHS. 12

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cance

    Evans, K. W., Yuca, E., Scott, S. S., Zhao, M., Paez Arango, N., Cruz Pico, C. X., Saridogan, T., Shariati, M., Class, C., Bristow, C. A., Vellano, C. P., Zheng, X., Gonzalez-Angulo, A. M., Su, X., Tapia, C., Chen, K., Akcakanat, A., Lim, B., Tripathy, D. & Yap, T. A. & 6 others, Di Francesco, M. E., Draetta, G. F., Jones, P., Heffernan, H. P., Marszalek, J. R. & Meric-Bernstam, F., Nov 1 2021, In: Scholarship and Professional Work – COPHS. 21

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

    Giuliani, V., Miller, M. A., Liu, C.-Y., Hartono, S. R., Class, C., Bristow, C. A., Suzuki, E., Sanz, L. A., Gao, G., Gay, J. P., Feng, N., Rose, J. L., Tomihara, H., Daniele, J. R., Peoples, M. D., Bardenhagen, J. P., Geck Do, M. K., Chang, Q. E., Vangamudi, B. & Vellano, C. & 18 others, Ying, H., Deem, A. K., Do, K.-A., Genovese, G., Heffernan, T. P., Kovacs, J. J., Kim, M., Fleming, J. B., Guccione, E., Viale, A., Maitra, A., Di Francesco, M. E., Yap, T. A., Jones, P., Draetta, G., Carugo, A., Chedin, F. & Heffernan, T. P., Jul 30 2021, In: Scholarship and Professional Work – COPHS. 12

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
View all 30 Research outputs