APOE ɛ4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy

Jessica S. Chapin; Robyn M. Busch; Damir Janigro; Michelle Dougherty; Christiane Q. Tilelli; Tara T. Lineweaver; Richard I. Naugle; Ramon Diaz-Arrastia; Imad M. Najm

doi:10.1016/j.eplepsyres.2008.05.003

APOE ɛ4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy

Jessica S. Chapin, Robyn M. Busch, Damir Janigro, Michelle Dougherty, Christiane Q. Tilelli, Tara T. Lineweaver, Richard I. Naugle, Ramon Diaz-Arrastia, Imad M. Najm

Research output: Contribution to journal › Article › peer-review

Abstract

This study examined the relationship between the APOE ɛ4 allele and postictal confusion in patients with medically intractable temporal lobe epilepsy (TLE). Patients with at least one ɛ4 allele ( n = 22) were three times more likely to exhibit postictal confusion (68%) than the 63 patients without ɛ4 (43%). These preliminary results demonstrate that APOE ɛ4 is associated with an increased risk of postictal confusion in patients with medically intractable TLE, suggesting possible dysfunction in neuronal recovery mechanisms.

Original language	American English
Journal	Scholarship and Professional Work - LAS
Volume	81
Issue number	2
DOIs	https://doi.org/10.1016/j.eplepsyres.2008.05.003
State	Published - Jan 1 2008

Keywords

APOE
Apolipoprotein E
Neuronal recovery
Postictal confusion
Seizures
Temporal lobe epilepsy

Disciplines

Clinical Psychology
Psychology

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title = "APOE ɛ4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy",

abstract = " This study examined the relationship between the APOE ɛ4 allele and postictal confusion in patients with medically intractable temporal lobe epilepsy (TLE). Patients with at least one ɛ4 allele ( n = 22) were three times more likely to exhibit postictal confusion (68\%) than the 63 patients without ɛ4 (43\%). These preliminary results demonstrate that APOE ɛ4 is associated with an increased risk of postictal confusion in patients with medically intractable TLE, suggesting possible dysfunction in neuronal recovery mechanisms.",

keywords = "APOE, Apolipoprotein E, Neuronal recovery, Postictal confusion, Seizures, Temporal lobe epilepsy",

author = "Chapin, \{Jessica S.\} and Busch, \{Robyn M.\} and Damir Janigro and Michelle Dougherty and Tilelli, \{Christiane Q.\} and Lineweaver, \{Tara T.\} and Naugle, \{Richard I.\} and Ramon Diaz-Arrastia and Najm, \{Imad M.\}",

note = "Chapin, J.S., Busch, R.M., Janigro, D., Doughtery, M., Tilelli, C., Lineweaver, T. T., Naugle, R.I., Diaz-Arrastia, R. \& Najm, I. (2008). APOE ε4 is Associated with Postictal Confusion in Patients with Medically Refractory Temporal Lobe Epilepsy. Epilepsy Research, 81, 220-224. doi: 10.1016/j.eplepsyres.2008.05.003 Available from: digitalcommons.butler.edu/facsch\_papers/434/",

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T1 - APOE ɛ4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy

AU - Chapin, Jessica S.

AU - Busch, Robyn M.

AU - Janigro, Damir

AU - Dougherty, Michelle

AU - Tilelli, Christiane Q.

AU - Lineweaver, Tara T.

AU - Naugle, Richard I.

AU - Diaz-Arrastia, Ramon

AU - Najm, Imad M.

N1 - Chapin, J.S., Busch, R.M., Janigro, D., Doughtery, M., Tilelli, C., Lineweaver, T. T., Naugle, R.I., Diaz-Arrastia, R. & Najm, I. (2008). APOE ε4 is Associated with Postictal Confusion in Patients with Medically Refractory Temporal Lobe Epilepsy. Epilepsy Research, 81, 220-224. doi: 10.1016/j.eplepsyres.2008.05.003 Available from: digitalcommons.butler.edu/facsch_papers/434/

PY - 2008/1/1

Y1 - 2008/1/1

N2 - This study examined the relationship between the APOE ɛ4 allele and postictal confusion in patients with medically intractable temporal lobe epilepsy (TLE). Patients with at least one ɛ4 allele ( n = 22) were three times more likely to exhibit postictal confusion (68%) than the 63 patients without ɛ4 (43%). These preliminary results demonstrate that APOE ɛ4 is associated with an increased risk of postictal confusion in patients with medically intractable TLE, suggesting possible dysfunction in neuronal recovery mechanisms.

AB - This study examined the relationship between the APOE ɛ4 allele and postictal confusion in patients with medically intractable temporal lobe epilepsy (TLE). Patients with at least one ɛ4 allele ( n = 22) were three times more likely to exhibit postictal confusion (68%) than the 63 patients without ɛ4 (43%). These preliminary results demonstrate that APOE ɛ4 is associated with an increased risk of postictal confusion in patients with medically intractable TLE, suggesting possible dysfunction in neuronal recovery mechanisms.

KW - APOE

KW - Apolipoprotein E

KW - Neuronal recovery

KW - Postictal confusion

KW - Seizures

KW - Temporal lobe epilepsy

UR - https://digitalcommons.butler.edu/facsch_papers/434

U2 - 10.1016/j.eplepsyres.2008.05.003

DO - 10.1016/j.eplepsyres.2008.05.003

M3 - Article

VL - 81

JO - Scholarship and Professional Work - LAS

JF - Scholarship and Professional Work - LAS

IS - 2

ER -

APOE ɛ4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy

Abstract

Keywords

Disciplines

Access to Document

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