Biodegradable Polymeric Carriers for Delivery of siRNA

S. Rege; Sudip Das; Nandita Das

Biodegradable Polymeric Carriers for Delivery of siRNA

S. Rege, Sudip Das, Nandita Das

Butler University

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

There are several barriers associated with the transport of siRNA to the target. These include catalytic enzymes, defense mechanisms, and other degradation processes. A number of studies showed that the polymeric nonviral vectors can be successfully used to target genes. Compared to the viral vectors, which possess a considerable risk of toxicity, nonviral vectors can be promising for gene delivery and their chemistry, toxicity, stability, and biodegradability can be modified to make them most suitable for gene delivery.

Original language	American English
Title of host publication	Bio-Targets and Drug Delivery Approaches
State	Published - Jan 1 2016

Keywords

RNA
drug delivery
gene targeting
siRNA

Disciplines

Medicinal and Pharmaceutical Chemistry
Medicine and Health Sciences
Pharmacy and Pharmaceutical Sciences

Access to Document

http://www.worldcat.org/oclc/950958210

Cite this

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title = "Biodegradable Polymeric Carriers for Delivery of siRNA",

abstract = " There are several barriers associated with the transport of siRNA to the target. These include catalytic enzymes, defense mechanisms, and other degradation processes. A number of studies showed that the polymeric nonviral vectors can be successfully used to target genes. Compared to the viral vectors, which possess a considerable risk of toxicity, nonviral vectors can be promising for gene delivery and their chemistry, toxicity, stability, and biodegradability can be modified to make them most suitable for gene delivery.",

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author = "S. Rege and Sudip Das and Nandita Das",

year = "2016",

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T1 - Biodegradable Polymeric Carriers for Delivery of siRNA

AU - Rege, S.

AU - Das, Sudip

AU - Das, Nandita

PY - 2016/1/1

Y1 - 2016/1/1

N2 - There are several barriers associated with the transport of siRNA to the target. These include catalytic enzymes, defense mechanisms, and other degradation processes. A number of studies showed that the polymeric nonviral vectors can be successfully used to target genes. Compared to the viral vectors, which possess a considerable risk of toxicity, nonviral vectors can be promising for gene delivery and their chemistry, toxicity, stability, and biodegradability can be modified to make them most suitable for gene delivery.

AB - There are several barriers associated with the transport of siRNA to the target. These include catalytic enzymes, defense mechanisms, and other degradation processes. A number of studies showed that the polymeric nonviral vectors can be successfully used to target genes. Compared to the viral vectors, which possess a considerable risk of toxicity, nonviral vectors can be promising for gene delivery and their chemistry, toxicity, stability, and biodegradability can be modified to make them most suitable for gene delivery.

KW - RNA

KW - drug delivery

KW - gene targeting

KW - siRNA

UR - https://digitalcommons.butler.edu/cophs_papers/236

UR - http://www.worldcat.org/oclc/950958210

M3 - Chapter

BT - Bio-Targets and Drug Delivery Approaches

ER -

Biodegradable Polymeric Carriers for Delivery of siRNA

Abstract

Keywords

Disciplines

Access to Document

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Cite this