Differential effects of Alzheimer's disease and Huntington's disease on the performance of mental rotation

Tara T. Lineweaver; David P. Salmon; Mark W. Bondi; Jody Corey-Bloom

doi:10.1017/S1355617705050034

Differential effects of Alzheimer's disease and Huntington's disease on the performance of mental rotation

Tara T. Lineweaver, David P. Salmon, Mark W. Bondi, Jody Corey-Bloom

Research output: Contribution to journal › Article › peer-review

Abstract

he ability to spatially rotate a mental image was compared in patients with Alzheimer's disease (AD; n = 18) and patients with Huntington's disease (HD; n = 18). Compared to their respective age-matched normal control (NC) group, the speed, but not the accuracy, of mental rotation abnormally decreased with increasing angle of orientation for patients with HD. In contrast, the accuracy, but not the speed, of rotation abnormally decreased with increasing angle of orientation for patients with AD. Additional analyses showed that these unique patterns of performance were not attributable to different speed/accuracy trade-off sensitivities. This double dissociation suggests that the distinct brain regions affected in the two diseases differentially contribute to speed and accuracy of mental rotation. Specifically, the slowing exhibited by HD patients may be mediated by damage to the basal ganglia, whereas the spatial manipulation deficit of AD patients may reflect pathology in parietal and temporal lobe association cortices important for visuospatial processing. ( JINS , 2005, 11 , 30–39.)

Original language	American English
Journal	Scholarship and Professional Work - LAS
Volume	11
Issue number	1
DOIs	https://doi.org/10.1017/S1355617705050034
State	Published - Jan 1 2005

Keywords

Alzheimer's
Basal ganglia
Huntington's
Mental rotation
Parietal lobe

Disciplines

Clinical Psychology
Psychology

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Differential effects of Alzheimers disease and Huntingtons diseFinal published version, 905 KBLicense: Unspecified

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title = "Differential effects of Alzheimer's disease and Huntington's disease on the performance of mental rotation",

abstract = " he ability to spatially rotate a mental image was compared in patients with Alzheimer's disease (AD; n = 18) and patients with Huntington's disease (HD; n = 18). Compared to their respective age-matched normal control (NC) group, the speed, but not the accuracy, of mental rotation abnormally decreased with increasing angle of orientation for patients with HD. In contrast, the accuracy, but not the speed, of rotation abnormally decreased with increasing angle of orientation for patients with AD. Additional analyses showed that these unique patterns of performance were not attributable to different speed/accuracy trade-off sensitivities. This double dissociation suggests that the distinct brain regions affected in the two diseases differentially contribute to speed and accuracy of mental rotation. Specifically, the slowing exhibited by HD patients may be mediated by damage to the basal ganglia, whereas the spatial manipulation deficit of AD patients may reflect pathology in parietal and temporal lobe association cortices important for visuospatial processing. ( JINS , 2005, 11 , 30–39.)",

keywords = "Alzheimer's, Basal ganglia, Huntington's, Mental rotation, Parietal lobe",

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note = "Lineweaver, T. T., Salmon, D. P., Bondi, M. W. \& Corey-Bloom, J. (2005). Differential Effects of Alzheimer{\textquoteright}s Disease and Huntington{\textquoteright}s Disease on the Performance of Mental Rotation. Journal of the International Neuropsychological Society, 11, 30-39. doi: 10.1017/S1355617705050034 Available from: digitalcommons.butler.edu/facsch\_papers/438/",

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AU - Salmon, David P.

AU - Bondi, Mark W.

AU - Corey-Bloom, Jody

N1 - Lineweaver, T. T., Salmon, D. P., Bondi, M. W. & Corey-Bloom, J. (2005). Differential Effects of Alzheimer’s Disease and Huntington’s Disease on the Performance of Mental Rotation. Journal of the International Neuropsychological Society, 11, 30-39. doi: 10.1017/S1355617705050034 Available from: digitalcommons.butler.edu/facsch_papers/438/

PY - 2005/1/1

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N2 - he ability to spatially rotate a mental image was compared in patients with Alzheimer's disease (AD; n = 18) and patients with Huntington's disease (HD; n = 18). Compared to their respective age-matched normal control (NC) group, the speed, but not the accuracy, of mental rotation abnormally decreased with increasing angle of orientation for patients with HD. In contrast, the accuracy, but not the speed, of rotation abnormally decreased with increasing angle of orientation for patients with AD. Additional analyses showed that these unique patterns of performance were not attributable to different speed/accuracy trade-off sensitivities. This double dissociation suggests that the distinct brain regions affected in the two diseases differentially contribute to speed and accuracy of mental rotation. Specifically, the slowing exhibited by HD patients may be mediated by damage to the basal ganglia, whereas the spatial manipulation deficit of AD patients may reflect pathology in parietal and temporal lobe association cortices important for visuospatial processing. ( JINS , 2005, 11 , 30–39.)

AB - he ability to spatially rotate a mental image was compared in patients with Alzheimer's disease (AD; n = 18) and patients with Huntington's disease (HD; n = 18). Compared to their respective age-matched normal control (NC) group, the speed, but not the accuracy, of mental rotation abnormally decreased with increasing angle of orientation for patients with HD. In contrast, the accuracy, but not the speed, of rotation abnormally decreased with increasing angle of orientation for patients with AD. Additional analyses showed that these unique patterns of performance were not attributable to different speed/accuracy trade-off sensitivities. This double dissociation suggests that the distinct brain regions affected in the two diseases differentially contribute to speed and accuracy of mental rotation. Specifically, the slowing exhibited by HD patients may be mediated by damage to the basal ganglia, whereas the spatial manipulation deficit of AD patients may reflect pathology in parietal and temporal lobe association cortices important for visuospatial processing. ( JINS , 2005, 11 , 30–39.)

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KW - Basal ganglia

KW - Huntington's

KW - Mental rotation

KW - Parietal lobe

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IS - 1

ER -

Differential effects of Alzheimer's disease and Huntington's disease on the performance of mental rotation

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