Insular Cortex Lesions and Morphine-Induced Suppression of Conditioned Stimulus Intake in the Rat

Christopher T. Roman; Steve Reilly

doi:10.1037/a0014308

Insular Cortex Lesions and Morphine-Induced Suppression of Conditioned Stimulus Intake in the Rat

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Abstract

The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin consumption of IC-lesioned rats. The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty.

Original language	American English
Journal	Scholarship and Professional Work – COPHS
Volume	123
Issue number	1
DOIs	https://doi.org/10.1037/a0014308
State	Published - Jan 1 2009

Keywords

Insular cortex
morphine
novelty perception
rat
relative value
taste

Disciplines

Behavioral Neurobiology
Neuroscience and Neurobiology

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10.1037/a0014308License: Unspecified

Insular Cortex Lesions and Morphine-Induced Suppression of ConditFinal published version, 1.09 MBLicense: Unspecified

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title = "Insular Cortex Lesions and Morphine-Induced Suppression of Conditioned Stimulus Intake in the Rat",

abstract = " The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin consumption of IC-lesioned rats. The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty.",

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N2 - The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin consumption of IC-lesioned rats. The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty.

AB - The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin consumption of IC-lesioned rats. The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty.

KW - Insular cortex

KW - morphine

KW - novelty perception

KW - rat

KW - relative value

KW - taste

UR - https://digitalcommons.butler.edu/cophs_papers/167

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JO - Scholarship and Professional Work – COPHS

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ER -

Insular Cortex Lesions and Morphine-Induced Suppression of Conditioned Stimulus Intake in the Rat

Abstract

Keywords

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