Self-assembling Modified β -cyclodextrin Conjugated siRNA Nanoparticles and Liposomal siRNA Efficiently Knock Down the Mutant Huntingtin Gene in a Modified PC-12 Cell Line

Rukmini Ladi; Sudip Das; Nandita Das

Self-assembling Modified β -cyclodextrin Conjugated siRNA Nanoparticles and Liposomal siRNA Efficiently Knock Down the Mutant Huntingtin Gene in a Modified PC-12 Cell Line

Rukmini Ladi, Sudip Das, Nandita Das

Butler University

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To formulate and characterize liposomal siRNA (LP-siRNA) and cationic β-cyclodextrin siRNA (CD-siRNA) nanoparticle complexes and evaluate their efficacy in knockdown of mutant Huntingtin protein (mHtt) in a modified PC-12 cell line.

Original language	American English
Journal	Scholarship and Professional Work – COPHS
State	Published - Jan 1 2015

Keywords

CD-siRNA
Huntingin
LP-siRNA
Liposomes
Mutant Huntingtin Gene

Disciplines

Medicinal and Pharmaceutical Chemistry
Medicine and Health Sciences
Pharmacy and Pharmaceutical Sciences

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Self-assembling Modified -cyclodextrin Conjugated siRNA NanopaFinal published version, 375 KBLicense: Unspecified

Cite this

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title = "Self-assembling Modified β -cyclodextrin Conjugated siRNA Nanoparticles and Liposomal siRNA Efficiently Knock Down the Mutant Huntingtin Gene in a Modified PC-12 Cell Line",

abstract = " Purpose: To formulate and characterize liposomal siRNA (LP-siRNA) and cationic β-cyclodextrin siRNA (CD-siRNA) nanoparticle complexes and evaluate their efficacy in knockdown of mutant Huntingtin protein (mHtt) in a modified PC-12 cell line.",

keywords = "CD-siRNA, Huntingin, LP-siRNA, Liposomes, Mutant Huntingtin Gene",

author = "Rukmini Ladi and Sudip Das and Nandita Das",

year = "2015",

month = jan,

day = "1",

language = "American English",

journal = "Scholarship and Professional Work – COPHS",

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TY - JOUR

T1 - Self-assembling Modified β -cyclodextrin Conjugated siRNA Nanoparticles and Liposomal siRNA Efficiently Knock Down the Mutant Huntingtin Gene in a Modified PC-12 Cell Line

AU - Ladi, Rukmini

AU - Das, Sudip

AU - Das, Nandita

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose: To formulate and characterize liposomal siRNA (LP-siRNA) and cationic β-cyclodextrin siRNA (CD-siRNA) nanoparticle complexes and evaluate their efficacy in knockdown of mutant Huntingtin protein (mHtt) in a modified PC-12 cell line.

AB - Purpose: To formulate and characterize liposomal siRNA (LP-siRNA) and cationic β-cyclodextrin siRNA (CD-siRNA) nanoparticle complexes and evaluate their efficacy in knockdown of mutant Huntingtin protein (mHtt) in a modified PC-12 cell line.

KW - CD-siRNA

KW - Huntingin

KW - LP-siRNA

KW - Liposomes

KW - Mutant Huntingtin Gene

UR - https://digitalcommons.butler.edu/cophs_papers/234

M3 - Article

JO - Scholarship and Professional Work – COPHS

JF - Scholarship and Professional Work – COPHS

ER -

Self-assembling Modified β -cyclodextrin Conjugated siRNA Nanoparticles and Liposomal siRNA Efficiently Knock Down the Mutant Huntingtin Gene in a Modified PC-12 Cell Line

Abstract

Keywords

Disciplines

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